Cambridge biotech tracker · Cambridge
Spero Therapeutics
Listed on Nasdaq as SPRO, filed under SEC industry code 2834 (pharmaceutical preparations). Fiscal year ends in December. Numbers below are from the company’s own SEC filings through Q2 '26.
- Cash & investments
- $50.8M
- Q2 '26 · Jun 29, 2026
- Burn per quarter
- None
- avg. operating cash flow, 4 qtrs
- Runway
- Self-funding
- Self-funding
- Net loss
- $9.6M
- Q2 '26
- R&D expense
- $3.4M
- 35% of opex
- Raised, last 4 qtrs
- $0
- net financing cash flow
Cash & investments
Quarter-end balance
Operating cash flow
Per quarter; below zero is burn
R&D expense
Per quarter
The controller’s read
What the filings say.
Generated from the numbers above using the same questions I ask when I open a client’s books: how long the cash lasts, what is driving the gap between loss and burn, and where the accounting judgment sits.
Get this read on your companySelf-funding on an operating basis
Operating cash flow was positive on average over the last four quarters, so runway is not the constraint. Cash and investments stood at $50.8M at Q2 '26.
Cash position down $25.5M since Q3 '24
No meaningful financing inflows over the last four quarters, so the change is essentially operating burn. The balance is the number the board watches; the trend is the number the auditors watch.
Net loss runs $4.2M above cash burn
The Q2 '26 net loss of $9.6M includes non-cash charges, including $822K of stock-based compensation, that do not consume cash. Burn, not net loss, is what runway is built on.
R&D is 35% of operating expenses
$3.4M of R&D against $9.9M of total operating expenses in Q2 '26, with G&A at $6.5M. For a clinical-stage company, the accounting questions live inside that R&D line: CRO and CMC accruals, milestone recognition, and what gets capitalized versus expensed under ASC 730.
Accumulated deficit of $468M
Total losses since inception. It is also roughly the size of the net operating loss carryforward the tax provision has to track, subject to Section 382 limits after each ownership change.
Cash-only balance shown
This company either holds no marketable securities or tags them under a name the tracker does not read. If the 10-Q reports a larger cash-and-investments figure, that figure is the right one.
Quarterly detail, eight quarters
| Quarter | Cash & inv. | Op. cash flow | Net loss | R&D | G&A | Revenue | Stock comp | Financing |
|---|---|---|---|---|---|---|---|---|
| Q3 '24 · Sep 29, 24 | $76.3M | $12.8M | −$17.1M | $26.9M | $5.2M | $13.5M | $2.2M | — |
| Q4 '24 · Dec 30, 24 | $52.9M | −$23.4M | −$20.9M | $28.8M | $7.1M | $15.0M | $1.5M | $0 |
| Q1 '25 · Mar 30, 25 | $48.9M | −$4.0M | −$13.9M | $13.6M | $6.8M | $5.9M | $1.6M | — |
| Q2 '25 · Jun 29, 25 | $31.2M | −$17.7M | −$1.7M | $10.7M | $5.9M | $14.2M | $714K | — |
| Q3 '25 · Sep 29, 25 | $48.6M | $17.4M | −$7.4M | $8.6M | $4.2M | $5.4M | $1.0M | — |
| Q4 '25 · Dec 30, 25 | $40.3M | −$8.4M | $31.5M | $5.6M | $4.3M | $41.3M | $1.0M | — |
| Q1 '26 · Mar 30, 26 | $56.1M | $15.9M | −$7.2M | $2.9M | $4.9M | $258K | $1.1M | — |
| Q2 '26 · Jun 29, 26 | $50.8M | −$5.4M | −$9.6M | $3.4M | $6.5M | $0 | $822K | — |
Source: SEC EDGAR XBRL company facts, latest filed value for each period. Fourth quarters are derived from annual less nine-month figures; quarterly cash flows are derived from year-to-date amounts. Not investment advice. If a figure disagrees with the filing, the filing is right.